Drug Data

Chemical Name: a¹-[[(1,1-Dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol

Synonyms: a¹-[(tert-butylamino)-methyl]-4-hydroxy-m-xylene-a,a´-diol

Merck Index Number: 217 (12^th Edition)

CAS Registry Number: 18559-94-9

RCI Class: 3

Molecular Formula: C₁₃H₂₁NO₃

  Molecular Weight: 239.31

  Melting Point: 185-195 ° (hydrochloride salt)

  Method: TIP SOP validated method developed by the Pennsylvania Equine Toxicology and Research Laboratory; detection by Generic Bronchodilator ELISA (Neogen Corporation); identification by GCMS.

Therapeutic Use: bronchodilator

Metabolites:

Standard Sample: Sigma S8260 (free base); Sigma S5013 (hemisulfate salt)

Reference Material:

GCMS:  EI                        TMS               Back to ACDIndex

Chemical Name: 2-Chloro-11-(piperazinyl)dibenz[b,f][1,4]oxazepine

Synonyms: CL-67772

Merck Index Number: 217 (12^th Edition)

CAS Registry Number: 14028-44-5

RCI Class: 2

Molecular Formula: C₁₇H₁₆ClN₃O

  Molecular Weight: 313.79

  Melting Point: 175-176 °

  Method: TIP SOP validated method developed by the Texas Veterinary Medical Diagnostic Laboratory; detection by Generic Bronchodilator TLC; identification by GCMS.

Therapeutic Use: antidepressant

Metabolites: conjugates of 7-hydroxyamoxazine

Standard Sample:

Reference Material:

Animal Drugs Chemical Data: Carprofen Back to Top

Chemical Name: 6-Chloro-a-methyl-9H-carbazole-2-acetic acid

Synonyms: C-5720; Ro-20-5720/000

Merck Index Number: 1912 (12^th Edition)

CAS Registry Number: 53176-49-7

RCI Class: 4

Molecular Formula: C₁₅H₁₂ClNO₂

  Molecular Weight: 273.72

  Melting Point: 197-198 °

  Method: TIP SOP validated method developed by Truesdail Laboratories; detection by TLC; identification by GCMS

Therapeutic Use: anti-inflammatory; analgesic

Metabolites:

Standard Sample:

Reference Material:

Chemical Name: 4-Amino-3,5-dichloro-a-[[(1,1,-dimethylethyl)amino]methyl] benzenemethanol

Synonyms: 4-Amino-a-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol

Merck Index Number: 2407 (12^th Edition)

CAS Registry Number: 37148-27-9

RCI Class: 3

Molecular Formula: C₁₂H₁₈Cl₂N₂O

  Molecular Weight: 277.19

  Melting Point: 174-175.5 ° (hydrochloride salt)

  Method: validated method developed by the OSU Analytical Toxicology Laboratory; detection by Clenbuterol ELISA (Neogen Corporation); GCMS identification

Therapeutic Use: bronchodilator, repartitioning agent, tocolytic agent

Metabolites: no major identified metabolites

Standard Sample: Sigma C5423

Reference Material: CRM 329 for urine

Chemical Name: [1R-(exo, exo)]-3-(Benzoyloxy)-8-methyl-8-azabicyclo[3,2,1]octane-2-carboxylic acid methyl ester

Synonyms: 3ß-hydroxy-1aH,5aH-tropane-2ß-carboxylic acid methyl ester benzoate

Merck Index Number: 2517 (12^th Edition)

CAS Registry Number: 50-36-2

RCI Class: 1

Molecular Formula: C₁₇H₂₁NO₄

  Molecular Weight: 303.36

  Melting Point: 98°

  Method: validated method developed by OSU Analytical Toxicology Laboratory; detection by Cocaine ELISA (Elisa Technologies, Inc.) and fluorescence polarization immunoassay for benzoylecgonine (Abbott Laboratories); identification by GCMS

Therapeutic Use: local anesthetic

Metabolites: benzoylecgonine; ecgonine methyl ester

Standard Sample: benzoylecgonine available from Sigma (B4147), Radian (B-007 and B-004); benzoylecgonine-d3 available from Radian (B-008)

Reference Material: Lyphocheck® Urine Toxicology Screen Control (Bio-Rad)

Chemical Name: [5R-(5a,11a,13S*)]-13-Amino-5,6,7,8,9,10,11,12-octahydro-5-methyl-5,11-methanobenzocyclodecen-3-ol

Synonyms: Wy-16225

Merck Index Number: 2998 (12^th Edition)

CAS Registry Number: 53648-55-8

RCI Class: 2

Molecular Formula: C₁₆H₂₃NO

  Molecular Weight: 245.36

  Melting Point: 269-270 ° (hydrobromide salt)

  Method: TIP SOP validated method developed by Truesdail Laboratories; detection by TLC; identification by GCMS

Therapeutic Use: analgesic

Metabolites:

Standard Sample:

Reference Material:

Chemical Name: [5a,7a(R)]-4,5-Epoxy-3-hydroxy-6-methoxy-a,17-dimethyl-a-propyl-6,14-ethenomorphinan-7-methanol

Synonyms: tetrahydro-7a-(1-hydroxy-1-methylbutyl)-6,14-endo-ethenooripavine; hydrochloride as M-99

Merck Index Number: 3932 (12^th Edition)

CAS Registry Number: 14521-96-1

RCI Class: 1

Molecular Formula: C₂₅H₃₃NO₄

  Molecular Weight: 411.54

  Melting Point: 206 ° (hydrochloride salt)

  Method: TIP SOP validated method developed by Industrial Laboratories; detection by Etorphine ELISA (Neogen Corporation); identification by GCMS

Therapeutic Use: animal tranquilizer; potent narcotic analgesic

Metabolites: conjugates of etorphine

Standard Sample:

Reference Material:

Chemical Name: (±)-N-Methyl-g-[4-(trifluoromethyl)-phenoxy]benzenepropanamine

Synonyms: (±)-N-Methyl-3-phenyl-3-[(a,a,a-trifluoro-p-tolyl)oxy]propylamine

Merck Index Number: 4222 (12^th Edition)

CAS Registry Number: 54910-89-3

RCI Class: 3

Molecular Formula: C₁₇H₁₈F₂NO

  Molecular Weight: 309.33

  Melting Point: 158.4-158.9 ° (hydrochloride salt)

  Method: method validated by OSU Analytical Toxicology Laboratory; detection by Fluoxetine ELISA (Neogen Corporation), identification by GCMS.

Therapeutic Use: Antidepressant

Metabolites: N-Desmethylfluoxetine

Standard Sample: Eli Lilly Research Laboratories, Indianapolis, Indiana; Alltech-Applied Science Laboratories, State College, PA; fluoxetine-d₅ from Isotec, Miamisburg, Ohio

Reference Material:

Chemical Name: a-Phenyl-2-piperidineacetic acid methyl ester

Synonyms: methyl phenidylacetate; methyl a-phenyl-a-(2-piperidyl)acetate

Merck Index Number: 6186 (12^th Edition)

CAS Registry Number: 113-45-1

RCI Class: 1

Molecular Formula: C₁₄H₁₉NO₂

  Molecular Weight: 233.31

  Melting Point: 224-226 ° (hydrochloride salt)

  Method: TIP Approved Method PA Equine Toxicology & Research Laboratory; detection by TLC, identification by GCMS.

Therapeutic Use: CNS stimulant

Metabolites: ritalinic acid

Standard Sample: Sigma M2892

Reference Material:

GCMS: EI                        HFB    
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Chemical Name: 1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol

Synonyms: (±)-1-(isopropylamino)-3-[p-(b-methoxyethyl)phenoxy]-2-propanol

Merck Index Number: 6235 (12^th Edition)

CAS Registry Number: 37350-58-6

RCI Class: 3

Molecular Formula: C₁₅H₂₅NO₃

  Molecular Weight: 267.38

  Melting Point: 120-123 ° (tartrate salt)

  Method: TIP validated method developed by the PA Equine Toxicology & Research Laboratory; detection by Generic Bronchodilator ELISA (Neogen Corporation), identification by GCMS.

Therapeutic Use: antihypertensive; antianginal; antiarrhythmic

Metabolites:

Standard Sample: Sigma M5391

Reference Material:

GCMS: EI                        TMS
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Chemical Name: 4-(6-Methoxy-2-naphthalenyl)-2-butanone

Synonyms: 4-(6-methoxy-2-naphthyl)butan-2-one; BRL 14777

Merck Index Number: 6428 (12^th Edition)

CAS Registry Number: 42924-53-8

RCI Class: 4

Molecular Formula: C₁₅H₁₆O₂

  Molecular Weight: 228.29

  Melting Point: 80 °

  Method: TIP validated method developed by the PA Equine Toxicology & Research Laboratory; TLC screening, GCMS identification of metabolite..

Therapeutic Use: anti-inflammatory; analgesic

Metabolites: base-labile conjugates of 6-methoxynaphthylacetic acid

Standard Sample: nabumetone and metabolite from SmithKline Beecham Pharmaceuticals

Reference Material:

GCMS (nabumetone) : EI                        NEAT    

GCMS (6-methoxynaphthylacetic acid) : EI                        TMS
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Chemical Name: 4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione

Synonyms: 4-butyl-1,2-diphenyl-3,5-dioxopyrazolidine

Merck Index Number: 7431 (12^th Edition)

CAS Registry Number: 50-33-9

RCI Class: not classified

Molecular Formula: C₁₉H₂₀N₂O₂

  Molecular Weight: 308.38

  Melting Point: 105 °

  Method: validated quantitative methods validated by OSU Analytical Toxicology Laboratory and The Texas Veterinary Medical Diagnostic Laboratory.

Therapeutic Use: analgesic; anti-inflammatory; antipyretic

Metabolites: oxyphenbutazone; g-hydroxyphenylbutazone

Standard Sample: USP Reference Standards

Reference Material:

GCMS: (Phenylbutazone)

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Animal Drugs Chemical Data: Sertraline Back to Top 

Chemical Name: (1S-cis)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine

Synonyms: (1S, 4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthylamine

Merck Index Number: 8612 (12^th Edition)

CAS Registry Number: 79617-96-2

RCI Class: 2

Molecular Formula: C₁₇H₁₇Cl₂N

  Molecular Weight: 306.23

  Melting Point: 243-245 ° (hydrochloride salt)

  Method: validated method developed by The Texas Veterinary Medical Diagnostic Laboratory; detection by TLC; identification by GCMS.

Therapeutic Use: antidepressant

Metabolites: N-desmethylsertraline; hydroxysertraline

Standard Sample:

Reference Material:

GCMS: (Sertraline)

GCMS: (N-Desmethylsertraline)

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Chemical Name: 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide

Synonyms:

Merck Index Number: 9172(12^th Edition)

CAS Registry Number: 103628-46-2

RCI Class: 4

Molecular Formula: C₁₄H₂₁N₃O₂S

  Molecular Weight: 295.41

  Melting Point: 169-171 ° (hydrochloride salt)

  Method: method validated by OSU Analytical Toxicology Laboratory; detection by TLC; identification by GCMS.

Therapeutic Use: antimigraine (5HT₁-receptor agonist)

Metabolites:

Standard Sample:

Reference Material:

GCMS: EI
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Chemical Name: (±)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol

Synonyms: (±)-1-[a-[(dimethylamino)methyl]-p-methoxybenzyl]cyclohexanol

Merck Index Number: 10079 (12^th Edition)

CAS Registry Number: 93413-69-5

RCI Class: 2

Molecular Formula: C₁₇H₂₇NO₂

  Molecular Weight: 277.41

  Melting Point: 215-217 ° (hydrochloride salt)

  Method: validated method developed by The Texas Veterinary Medical Diagnostic Laboratory; detection by TLC; identification by GCMS.

Therapeutic Use: antidepressant

Metabolites: O-desmethylvenlafaxine

Standard Sample:

Reference Material:

GCMS: (Venlafaxine)

GCMS: (O-desmethylvenlafaxine)

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Chemical Name: 2-[(2-Ethoxyphenoxy)methyl]morpholine

Synonyms: 2-(2-ethoxyphenoxymethyl)tetrahydro-1,4-oxazine; ICI-58834

Merck Index Number: 10116 (12^th Edition)

CAS Registry Number: 46817-91-8

RCI Class: 2

Molecular Formula: C₁₃H₁₉NO₃

  Molecular Weight: 237.30

  Melting Point: 185-186 ° (hydrochloride salt)

  Method: validated method developed by Truesdail Laboratories; detection by TLC; identification by GCMS.

Therapeutic Use: antidepressant

Metabolites:

Standard Sample: Imperial Chemical Industries

Reference Material:

GCMS: 

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